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KMID : 1059520140580010062
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Journal of the Korean Chemical Society
2014 Volume.58 No. 1 p.62 ~ p.67
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Synthesis and Biological Activity of (2-Substituted-4-methylthiazol-5-yl) (4-substituted piperazin-1-yl)methanone Derivatives
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Mhaske Pravin C.
Shelke Shivaji H.
Raundal Hemant N.
Jadhav Rahul P.
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Abstract
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In the present study a novel series of (2-substituted-4-methylthiazol-5-yl)(4-substituted piperazin-1-yl)methanone derivatives were synthesized by reaction of 2-substituted-4-methylthiazole-5-carboxylic acid with N-substituted benzyl piperazine by using 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDCl) and 1-hydroxybenzotriazole (HOBt) in DMF. All the newly synthesized compounds were characterized by spectral methods. The title compounds were screened for in vitro antibacterial activity. Most of the compounds show moderate to good antimicrobial activity.
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KEYWORD
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Thiazole, Piperazine, EDCl-HOBt, Antimicrobial activity
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